Piperazine → HCID 18186850, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of the product from step 1 above (1.29 g, 5.15 mmol), piperazine (1.30 g, 15.1 mmol) and K2CO3 (0.71 g, 5.14 mmol) in acetonitrile (5 mL) was heated in a sealed pyrex flask at 100° C. for 4 h. The reaction mixture was diluted with dichloromethane, filtered, and concentrated in vacuo. The light-brown semi-solid residue was purified by silica gel chromatography (15×4 cm) using CHCl3/MeOH (9:1) as eluent. Solvents were evaporated off and the residue was redissolved in ether/CHCl3 (1:1). Filtration and concentration in vacuo furnished 1.05 g (68%) of the title compound as a white solid. HRMS m/z calcd for C16H20N4O2 (M)+ 300.1586, found 300.1578. Anal. (C16H20N4O2) C, H, N.

Provenance & Evidence