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Piperazine → 2-[(2,5-Dimethoxybenzyl)Oxy]-6-(1-Piperazinyl)Pyrazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Piperazine | HCID 4837 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2,5-Dimethoxybenzyl alcohol | HCID 118495 | — |
| 反応物 | 2-Chloro-6-[(2,5-dimethoxybenzyl)oxy]pyrazine | HCID 18186869 | — |
| 生成物 | 2-[(2,5-Dimethoxybenzyl)Oxy]-6-(1-Piperazinyl)Pyrazine | HCID 9967301 | — |
反応手順
The title compound was prepared according to the procedure of example 50, step 2, starting from 2-chloro-6-[(2,5-dimethoxybenzyl)oxy]pyrazine (1.02 g, 3.63 mmol; obtained according to the procedure of example 50, step 1, starting from 2,5-dimethoxybenzyl alcohol), piperazine (0.94 g, 10.9 mmol) and K2CO3 (0.50 g, 3.63 mmol). The yield of the title compound was 0.64 g (53%) which was obtained as a beige solid. Purity 100% (HPLC). MS m/z 331 (M+H)+. HRMS m/z calcd for C17H22N4O3 (M)+ 330.1692, found 330.1692.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06593330B2 |
| 出典データセット | uspto-grants-2003_07 |
| ORD ID | ord-76ce447ff8fa44dfa0a765b6f4f29f4a |
| 出典メモ | uspto-grants-2003_07 |