反应详情

3-Bromo-4-fluorobenzaldehyde (305 mg, 1.5 mmol), tetrahydrothiophene-3-oxo-1,1-dioxide (402 mg, 3.00 mmol), and 2.0 M NH3 in ethanol (1,1 mL, 2.2 mmol) in ethanol (3 mL) were heated to 80° C. for 3 days in a sealed tube, cooled, the solid precipitate collected, and washed with ethanol. The solid was heated to reflux overnight in ethanol with 1.0 M HCl in ether (1 mL), cooled, the solid collected, washed with ethanol and dried to provide 185 mg of the title compound as an off-white solid.

1. temperaturecooled
2. customthe solid precipitate collected
3. washwashed with ethanol
4. temperatureThe solid was heated
5. temperatureto reflux overnight in ethanol with 1.0 M HCl in ether (1 mL)
6. temperaturecooled
7. customthe solid collected
8. washwashed with ethanol
9. customdried