反应详情

To a solution of 3-bromo-4-fluorobenzaldehyde (5.00 g, 24.6 mmol) in sulfuric acid (25 mL) at 0 ° C. was added dropwise fuming nitric acid (3 mL) in sulfuric acid (30 mL), stirred at room temperature overnight, poured onto ice, the precipitate collected, washed with water, and dried. The crude product was purified by flash chromatography over silica gel eluting with ethylacetate/hexane (3:7) to provide 3.9 g of the title compound as yellow crystals.

1. additionpoured onto ice
2. customthe precipitate collected
3. washwashed with water
4. customdried
5. customThe crude product was purified by flash chromatography over silica gel eluting with ethylacetate/hexane (3:7)