HCID 23381731, compound → HCID 88089993, compound

HRID 1357804Notes

Reaction equation

HRID 1357804 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][C:10]([NH:13][CH2:14][C:15]3[N:19]([CH3:20])[C:18]4[CH:21]=[CH:22][C:23]([C@@:25]([NH2:34])([C:27]([N:29]5[CH2:33][CH2:32][CH2:31][CH2:30]5)=[O:28])[CH3:26])=[CH:24][C:17]=4[N:16]=3)=[CH:9][CH:8]=2)[N:3]=1.Br[CH2:36][C:37]#[N:38].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:8]=[CH:9][C:10]([NH:13][CH2:14][C:15]3[N:19]([CH3:20])[C:18]4[CH:21]=[CH:22][C:23]([C@@:25]([NH:34][CH2:36][C:37]#[N:38])([C:27]([N:29]5[CH2:33][CH2:32][CH2:31][CH2:30]5)=[O:28])[CH3:26])=[CH:24][C:17]=4[N:16]=3)=[CH:11][CH:12]=2)[N:3]=1

Participants

4

Reactant 2

HCID 23381731HCID 23381731, compoundHCID 131723978HCID 131723978, compound

Product 1

HCID 88089993HCID 88089993, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Prepared analogously to Example 1k from (R)-2-[4-(5-methyl-1,2,4-oxadiazol-3-yl)-phenylaminomethyl]-1-methyl-5-[1-amino-1-(pyrrolidinocarbonyl)-ethyl]-benzimidazole and bromoacetonitrile/potassium carbonate in acetone.

Sources & evidence

ORD record
ord-2a08cf4642114015ac584e4d436002e1
Source dataset
uspto-grants-2003_07
Patent number
US06593355B2

Reaction notes

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