HCID 18188138, compound → HCID 178480665, compound

HRID 1357812Notes

Reaction equation

HRID 1357812 reaction equation
[CH3:1][NH:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([CH3:23])([CH2:17][C:18]2[NH:22][N:21]=[N:20][N:19]=2)[C:10]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)=[O:11])=[CH:5][C:4]=1[NH2:24].[C:25]([C:27]1[CH:32]=[CH:31][C:30]([NH:33][CH2:34][C:35](O)=O)=[CH:29][CH:28]=1)#[N:26].F[B-](F)(F)F.N1(OC(N(C)C)=[N+](C)C)C2C=CC=CC=2N=N1>C(O)(=O)C>[C:25]([C:27]1[CH:28]=[CH:29][C:30]([NH:33][CH2:34][C:35]2[N:2]([CH3:1])[C:3]3[CH:8]=[CH:7][C:6]([C:9]([CH2:17][C:18]4[NH:22][N:21]=[N:20][N:19]=4)([C:10]([N:12]4[CH2:16][CH2:15][CH2:14][CH2:13]4)=[O:11])[CH3:23])=[CH:5][C:4]=3[N:24]=2)=[CH:31][CH:32]=1)#[N:26]

Participants

4

Reactant 2

HCID 18188138HCID 18188138, compoundHCID 178482142HCID 178482142, compound

Product 1

HCID 178480665HCID 178480665, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Prepared analogously to Example 1g/h from 2-[4-(N-methylamino)-3-amino-phenyl]-2-methyl-3-(1H-tetrazol-5-yl)-1-pyrrolidino-propan-1-one, 4-cyano-phenylglycine/O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate and subsequently treating with glacial acetic acid.

Sources & evidence

ORD record
ord-1127961ee8b94e538d2425be11962a30
Source dataset
uspto-grants-2003_07
Patent number
US06593355B2

Reaction notes

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