HCID 18188177, compound → HCID 18188143, compound

HRID 1357815Notes

Reaction equation

HRID 1357815 reaction equation
[CH3:1][NH:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([CH3:26])([CH2:17][NH:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[C:10]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)=[O:11])=[CH:5][C:4]=1[NH2:27].[C:28]([C:30]1[CH:35]=[CH:34][C:33]([NH:36][CH2:37][C:38](O)=O)=[CH:32][CH:31]=1)#[N:29].C(N1C=CN=C1)(N1C=CN=C1)=O>C(O)(=O)C>[C:28]([C:30]1[CH:31]=[CH:32][C:33]([NH:36][CH2:37][C:38]2[N:2]([CH3:1])[C:3]3[CH:8]=[CH:7][C:6]([C:9]([CH2:17][NH:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])([C:10]([N:12]4[CH2:13][CH2:14][CH2:15][CH2:16]4)=[O:11])[CH3:26])=[CH:5][C:4]=3[N:27]=2)=[CH:34][CH:35]=1)#[N:29]

Participants

4

Reactant 2

HCID 18188177HCID 18188177, compoundHCID 131723980HCID 131723980, compound

Product 1

HCID 18188143HCID 18188143, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Prepared analogously to Example 1g/h from 2-[4-(N-methylamino)-3-amino-phenyl]-2-methyl-3-(tert.butyloxycarbonylamino)-1-pyrrolidino-propan-1-one, 4-cyano-phenylglycine/carbonyldiimidazole and subsequent treatment with glacial acetic acid.

Sources & evidence

ORD record
ord-8427176a0e4249dbacaf448526389c7e
Source dataset
uspto-grants-2003_07
Patent number
US06593355B2

Reaction notes

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