HRID1357815

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CNc1ccc(C(C)(CNC(=O)OC(C)(C)C)C(=O)N2CCCC2)cc1N

HCID18188177

未命名化合物

结构：N#Cc1ccc(NCC(=O)O)cc1.O=C(n1ccnc1)n1ccnc1

HCID131723980

未命名化合物

PRODUCTS

生成物

结构：Cn1c(CNc2ccc(C#N)cc2)nc2cc(C(C)(CNC(=O)OC(C)(C)C)C(=O)N3CCCC3)ccc21

HCID18188143

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID176

Acetic Acid

C2H4O2

PROCEDURE

实验过程

Prepared analogously to Example 1g/h from 2-[4-(N-methylamino)-3-amino-phenyl]-2-methyl-3-(tert.butyloxycarbonylamino)-1-pyrrolidino-propan-1-one, 4-cyano-phenylglycine/carbonyldiimidazole and subsequent treatment with glacial acetic acid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8427176a0e4249dbacaf448526389c7e
来源数据集: uspto-grants-2003_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06593355B2
来源说明: uspto-grants-2003_07

反应 SMILES

[CH3:1][NH:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([CH3:26])([CH2:17][NH:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[C:10]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)=[O:11])=[CH:5][C:4]=1[NH2:27].[C:28]([C:30]1[CH:35]=[CH:34][C:33]([NH:36][CH2:37][C:38](O)=O)=[CH:32][CH:31]=1)#[N:29].C(N1C=CN=C1)(N1C=CN=C1)=O>C(O)(=O)C>[C:28]([C:30]1[CH:31]=[CH:32][C:33]([NH:36][CH2:37][C:38]2[N:2]([CH3:1])[C:3]3[CH:8]=[CH:7][C:6]([C:9]([CH2:17][NH:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])([C:10]([N:12]4[CH2:13][CH2:14][CH2:15][CH2:16]4)=[O:11])[CH3:26])=[CH:5][C:4]=3[N:27]=2)=[CH:34][CH:35]=1)#[N:29]