1-Bromo-2-Chloroethane → HCID 178478507, compound

Participants

Reaction Steps

5-Hydroxy-3-(2-thienyl)pyrazole (2.49 g), potassium carbonate (3.11 g) and 18-crown-6-ether (0.13 g) is suspended in acetonitrile (31 ml), to which 1-bromo-2-chloroethane (2.15 g) is added drop by drop and the reaction mixture is refluxed for 5 hours by heating. After the reaction is completed, it is extracted with ethyl acetate, washed with aqueous solution of sodium hydrogen carbonate and dried with anhydrous magnesium sulfate. Dichloromethane is added to the residue obtained by distilling off ethyl acetate and the insoluble matter is filtered off. Dichloromethane is added and distilled off to obtain the objective 5-(2-chloroethoxy)-3-(2-thienyl)pyrazole (1.0 g). mp. 134-138° C.

Provenance & Evidence