Methyl 3-hydroxy-5-methoxy-4-nitrophenylacetate → Methyl 4-amino-3-hydroxy-5-methoxy-phenylacetate

Participants

Reaction Steps

A solution of methyl 3-hydroxy-5-methoxy-4-nitrophenylacetate (0.34 g, Reference Example 11) in ethanol (25 mL) was treated with palladium on charcoal (approximately 0.035 g, 10%) and stirred under a hydrogen atmosphere. After 2 hours the mixture was filtered through a pad of celite and the filtrate was evaporated to give the title compound (0.3 g ) as a brown oil.

Provenance & Evidence