4-Fluoroaniline → N-(4-fluorophenyl)-2-(3-methoxyphenyl)acetamide

HRID 1357986Notes

Reaction equation

HRID 1357986 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:9][C:10](Cl)=[O:11])[CH:6]=[CH:7][CH:8]=1.[F:13][C:14]1[CH:20]=[CH:19][C:17]([NH2:18])=[CH:16][CH:15]=1>>[F:13][C:14]1[CH:20]=[CH:19][C:17]([NH:18][C:10](=[O:11])[CH2:9][C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[CH:4]=2)=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 97314-FluoroanilineHCID 27332463-Methoxyphenylacetyl chloride

Product 1

HCID 2704885N-(4-fluorophenyl)-2-(3-methoxyphenyl)acetamideYield 98%

Procedure

The title compound was prepared as described in Example 1.A, using 3-methoxyphenylacetyl chloride (3.29 g, 18.0 mmol) and 4-fluoroaniline (1.98 g, 18.0 mmol) to afford the title compound (4.57 g, 98% yield): ES-MS (m/z) 259.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-775fbe5e6c5545b0a0de76ac2f0bc43a
Source dataset
uspto-grants-2003_07
Patent number
US06593322B1

Reaction notes

Loading…