HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(4-Hydroxyphenyl)propionic acid → N-(4-Fluorophenyl)-3-(4-hydroxyphenyl)-N-{2-[3-(phenylmethoxy)phenyl]ethyl]propanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(4-Hydroxyphenyl)propionic acid | HCID 10394 | — |
| Reactant | (4-Fluorophenyl){2-[3-(phenylmethoxy)phenyl]ethyl}amine | HCID 23440828 | — |
| Product | N-(4-Fluorophenyl)-3-(4-hydroxyphenyl)-N-{2-[3-(phenylmethoxy)phenyl]ethyl]propanamide | HCID 23440768 | 89% |
Reaction Steps
The title compound was prepared as described in Example 44.D using (4-fluorophenyl){2-[3-(phenyl methoxy)phenyl]ethyl}amine (1.4 g, 4.36 mmol) and 3-(4-hydroxyphenyl)propanoic acid (1.01 g, 6.11 mmol) to provide the title compound (1.82 g, 89% yield): ES-MS (m/z) 470 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06593322B1 |
| Source dataset | uspto-grants-2003_07 |
| ORD ID | ord-56ad96e0437b400fada72c65b3e5ba97 |
| Source note | uspto-grants-2003_07 |