Methanol → Doxifluridine

Participants

Reaction Steps

When the reduction is carried out by using tributyltin hydride, the reaction takes place by dissolving 5′-deoxy-5′-iodo-5-fluorouridine in an alcohol, for example methanol, the reducing agent being added as a solution in an organic solvent, for example in toluene, and the mixture is heated at reflux in the presence of α,α′-azoisobutyro nitrile in catalytic amount. After 1÷3 hours the reduction is complete and, after evaporation of the solvent, the 5′-deoxy-5-fluorouridine thus obtained is recovered according to conventional methods.

Provenance & Evidence