Hydrochloric Acid → HCID 10141903, compound

Participants

Reaction Steps

A solution of Example 115 (110 mg, 0.21 mmol) and aqueous LiOH (1 ml of 10% solution) in methanol (1 ml) was stirred for 3 hours, neutralized with 1M HCl, and extracted with ethyl acetate. The extract was dried (MgSO4) and concentrated. The concentrate was purified by high throughput HPLC with aqueous 0.1% TFA and CH3CN to provide the titled compound. 1H NMR (300 MHz, DMSO-d6) δ 8.15 (d, J=9 Hz, 1H) 6.87-7.56 (m, 10H), 6.24 (s, 1H), 3.00 (s, 1H), 2.55 (t, J=7 Hz, 2H), 2.17 (t, J=7 Hz, 2H), 1.73 (m, J=7 Hz, 2H); MS (ESI(−)Q1MS m/z 502 (M−H).

Provenance & Evidence