Acetone → HCID 18003355, compound

HRID 1358168Notes

Reaction equation

HRID 1358168 reaction equation
[NH2:1][C:2]([CH3:10])([CH3:9])[CH2:3][NH:4][CH2:5][CH:6](O)[CH3:7].[CH:11](Cl)(Cl)Cl.[CH3:15][C:16]([CH3:18])=O.[OH-:19].[Na+].[OH2:21]>>[OH:19][CH:6]([CH3:7])[CH2:5][N:4]1[CH2:15][C:16]([CH3:18])([CH3:11])[NH:1][C:2]([CH3:10])([CH3:9])[C:3]1=[O:21]

Participants

6

Reactant 5

HCID 180AcetoneHCID 962WaterHCID 6212ChloroformHCID 14798Sodium HydroxideHCID 2268411-(2-amino-2-methylpropylamino)propan2-ol

Product 1

HCID 18003355HCID 18003355, compound

Procedure

Following the procedure described below in EXAMPLE 4A, step 3, 250 g (1.71 mol) of 1-(2-amino-2-methylpropylamino)propan-2-ol are reacted with 306.2 g (2.57 mol) of chloroform and 1509 ml of acetone in the presence of 410.4 g (10.26 mol) of sodium hydroxide in 410 ml of water. A yellow oil with a boiling point of 137°-140° C. at 1.1 mbar is obtained.

Workup

  1. customA yellow oil with a boiling point of 137°-140° C. at 1.1 mbar is obtained

Sources & evidence

ORD record
ord-f553ac911f684b51920da1c4b02c6a47
Source dataset
uspto-grants-2003_07
Patent number
US06596461B1

Reaction notes

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