Methyl iodide → HCID 9968986, compound

Participants

Reaction Steps

A suspension of compound (2R)-(3-amino-2-fluoropropyl)phosphinic acid (1.0 g, 7.1 mmol) in HMDS (7.47 mL, 35.4 mmol) was heated to reflux for 16 h. The reaction was cooled to room temperature, treated with diglyme (8.0 mL) and heated to reflux for 6 h. After the mixture was cooled to room temperature , Hünig's base (1.23 mL, 7.1 mmol) was added followed by dropwise addition of methyl iodide (1.32 mL, 21.2 mmol). The reaction was stirred for 23.5 h then it was diluted with methylene chloride and extracted with 2 N HCl solution. The aqueous layer was washed with methylene chloride and diethyl ether and then evaporated under reduced pressure. The crude product was passed through a Dowex 50WX8-200 mesh H+ form column eluting, with 1:1 methanol/water until no further material was detected by TLC analysis. The product was then eluted with 1:3 concentrated ammonium hydroxide solution/methanol. Further purification by column chromatography on silica gel eluting with methylene chloride, methanol, concentrated ammonium hydroxide solution (6:3:1) afforded (2R)-(3-amino-2-fluoropropyl)(methyl)phosphinic acid as a white solid (720 mg, 65%). 1H NMR (300 MHz, D2O) δ5.20 (m, 0.5H), 5.03 (m, 0.5H), 3.20-3.42 (m, 2H), 1.80-2.22 (m, 2H), 1.30 (d, J=14.0 Hz, 3H).

Provenance & Evidence