HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Tetrahydrofolic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (6S)-5,6,7,8-tetrahydrofolic acid | HCID 135398650 | — |
| Solvent | Water | HCID 962 | — |
| Product | Tetrahydrofolic acid | HCID 135444742 | — |
Reaction Steps
By dissolving 20 g of the resulting crystalline (6S)-tetrahydrofolic acid in 80 ml of water at pH 9 and subsequently slowly bringing the pH to 5.1 using hydrochloric acid, 4.5 g of crystalline (6S)-tetrahydrofolic acid with a chemical content of 94.0% and a (6S) percentage of 94.7 are obtained after seeding with crystalline (6S)-tetrahydrofolic acid. The water content after drying is 1.8%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06596721B2 |
| Source dataset | uspto-grants-2003_07 |
| ORD ID | ord-9924c693fc8743a19102a315f12e6061 |
| Source note | uspto-grants-2003_07 |