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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1358239Generated: October 30, 2026

Thionyl Chloride → 3-(Chloromethyl)-5-fluorobenzofuran

https://huagongshe.com/reaction/1358239

Reaction equation

Participants

RoleNameHCIDCharge
ReactantThionyl ChlorideHCID 24386—
ReactantHCID 18184309HCID 18184309—
CatalystDimethylformamideHCID 6228—
SolventDichloromethaneHCID 6344—
Product3-(Chloromethyl)-5-fluorobenzofuranHCID 18184314—

Reaction Steps

A solution of 5-fluorobenzofuran-3-ylmethanol (14 g) in methylene chloride (250 mL) was treated successively with 5 drops of dimethylformamide and thionyl chloride (28 mL). After stirring for 16 h at room temperature the reaction was concentrated in vacuo giving 3-chloromethyl-5-fluorobenzofuran as an oil (19.4 g).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06596722B2
Source datasetuspto-grants-2003_07
ORD IDord-85b6230b51dd41d899267ece7db4995d
Source noteuspto-grants-2003_07