Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | 3-(Chloromethyl)-5-fluorobenzofuran | HCID 18184314 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 18184310 | HCID 18184310 | 92.7% |
Reaction Steps
A suspension of sodium cyanide (10 g) in dimethylsulfoxide (150 mL) was heated to 80° C. followed by quick addition of a solution of 3-chloromethyl-5-fluorobenzofuran (10 g) in dimethylsulfoxide (50 mL). The mixture was kept at 80° C. for ½ h and then poured onto ice. Standard work-up with diethyl ether gave a dark crystalline material, 5-fluorobenzofuran-3-ylacetonitrile (8.8 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06596722B2 |
|---|
| Source dataset | uspto-grants-2003_07 |
|---|
| ORD ID | ord-d6fa03600dab41d1bb574695d849522f |
|---|
| Source note | uspto-grants-2003_07 |
|---|
