Sodium borohydride → HCID 9863133, compound

Participants

Reaction Steps

The compound of EXAMPLE 3 (0.093 g) in methanol (100 ml) was treated with sodium borohydride (0.3 g) and the mixture stirred overnight. Solvent was removed at reduced pressure the residue dissolved in ethyl acetate and washed with water and brine. The organic phase was dried (Na2SO4) solvent removed at reduced pressure and the residue triturated with diethyl ether to give the title compound (0.06 g) as a colourless solid. 1H NMR δ: 1.69 (2H, m), 1.87 (2H, m), 2.63 (3H, s), 2.67 (2H, m), 4.53 (1H, m), 5.01 (1H, d), 7.23-7.35 (3H, m), 7.79 (1H, dd), 8.29 (1H, dd), 8.36 (1H, s), 8.89 (1H, m), 9.90 (1H, s), 9.93 (1H, s). m/z (API+): 349 (MH+).

Provenance & Evidence