N4-(3-bromophenyl)-4,6,7-Quinazolinetriamine → N-(3-bromophenyl)pyrazino[2,3-g]quinazolin-4-amine

Participants

Reaction Steps

A mixture of 4-(3-bromoanilino)-6,7-diaminoquinazoline (90 mg, 0.27 mmol) and 1,4-dioxane-2,3-diol (0.2 g, 1.6 mmol) [Venuti, M. C.; Synthesis, 1982, 61-63] in MeOH (20 mL) is stirred at room temperature overnight to give a precipitate of 4-(3-bromoanilino)pyrazino[2,3-g]quinazoline (80 mg, 83%).

Provenance & Evidence