HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-tert.-butyl-N-[6-chloro-5-(p-tolyl)4-pyrimidinyl]-benzene sulfonamide → 4-tert.-butyl-N-{6-[2-(toluene-sulfonyl-methyl-amino)-ethoxy]-5-p-tolyl-pyrimidin-4-yl}-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-tert.-butyl-N-[6-chloro-5-(p-tolyl)4-pyrimidinyl]-benzene sulfonamide | HCID 22729415 | — |
| Reactant | N-(2-hydroxyethyl)-N-methyl-toluenesulfonamide | HCID 65663185 | — |
| Product | 4-tert.-butyl-N-{6-[2-(toluene-sulfonyl-methyl-amino)-ethoxy]-5-p-tolyl-pyrimidin-4-yl}-benzenesulfonamide | HCID 86759074 | — |
Reaction Steps
According to Example 24d) 100 mg 4-tert.-butyl-N-[6-chloro-5-(p-tolyl)-4-pyrimidinyl]-benzene sulfonamide was reacted with N-(2-hydroxyethyl)-N-methyl-toluenesulfonamide to give 14 mg 4-tert.-butyl-N-{6-[2-(toluene-sulfonyl-methyl-amino)-ethoxy]-5-p-tolyl-pyrimidin-4-yl}-benzenesulfonamide. LC-MS: tR=6.18 min, [M−1]−=607.54.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06596719B1 |
| Source dataset | uspto-grants-2003_07 |
| ORD ID | ord-9e9a25aa83b84f42bdf4d41fe9ffb757 |
| Source note | uspto-grants-2003_07 |