2-Thiophenesulfonyl chloride → HCID 18184230, compound

Participants

Reaction Steps

According to the procedure described in Example 4a) 100 mg 5isopropyl-N-[6-(2-aminoethoxy)-5-(o-methoxyphenoxy)-2-(4-pyridyl)-4-pyrimidinyl]-2-pyridine sulfonamide was reacted with thiophene-2-sulfonylchloride to give 85 mg 5-isopropyl-N-[6-(2-(2-thiophenesulfonylamino)-ethoxy)-5-(o-methoxyphenoxy)-2-(2-pyridyl)-4-pyrimidinyl]-2-pyridine sulfonamide. LC-MS: tR=4.78 min, [M+1]+=683.61, [M−1]−=681.70.

Provenance & Evidence