反应详情

20 g of morpholine were added dropwise to a solution, cooled with ice, of 19.5 g of 4-fluorobenzenesulfonyl chloride in 100 ml of toluene, and the mixture was heated under reflux for 1 hour. After cooling, the mixture was concentrated under reduced pressure, the residue was stirred with water and the precipitate was filtered off with suction, washed with water and recrystallized from isopropanol.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 1 hour
3. temperatureAfter cooling
4. concentrationthe mixture was concentrated under reduced pressure
5. filtrationthe precipitate was filtered off with suction
6. washwashed with water
7. customrecrystallized from isopropanol