Stannous chloride dihydrate → HCID 18184540, compound

Participants

Reaction Steps

A solution of N-(3-Benzyloxy-4-nitrophenethyl)-3,5-dibromo-4-methoxy-phenylacetamide (3.49 g, 0.006 mol) and tin (II) chloride dihydrate (16.10 g, 0.071 mol) in a mixture of ethanol (300 mL) and 1.2 N HCl (150 mL) was refluxed for 3h, cooled and concentrated. Tin salts were dissolved in 1N NaOH solution. The reaction mixture was extracted with methylene chloride 3 times. The extracts were dried over Na2SO4 and concentrated. A residue was crystallized from ethyl acetate-hexanes mixture. Yield 1.57 g (47.4%).

Provenance & Evidence