Hydrochloric Acid → HCID 18184522, compound

Participants

Reaction Steps

A solution of N-[6-benzyloxy-1-(3,5-dibromo-4-methoxy-benzyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]-methanesulfonamide oxalate (3.98 g, 0.0057 mol) in a mixture of conc. HCl (50 mL) and methanol (50 mL) was refluxed for 1h, cooled and concentrated. A residue was crystallized from methanol—ethyl ether mixture. Yield 2.75 g (87%), M.p. 244-245° C. (dec.). 1H NMR (300 MHz, DMSO) δ 2.9 (s, 3H), 2.95-3.22 (m, 4H), 3.25-3.45 (m, 2H), 3.79 (s, 3H), 4.67 (m, 1H), 6.75 (s, 1H), 7.15 (s, 1H), 7.79 (s, 2H), 8.84 (s, 1H), 9.26 (d, J=12.6 Hz, 2H), 10.18 (s, 1H). Anal. (C18H21Br2ClN2O4S) calcd., C 38.83, H 3.80, N 5.03; found C 38.91, N 4.83.

Provenance & Evidence