Benzyl isocyanate → HCID 11478533, compound

Participants

Reaction Steps

To a solution of 1-[(R)-4-(6-aminoindol-1-yl)-1-(tert-butyldimethylsilyloxy)-2-butyl]imidazole-4-carboxamide (100 mg, 0.234 mmol) in THF (5 ml) was added dropwise benzylisocyanate (32 μl, 0.257 mmol). The reaction mixture was stirred at room temperature for 2 hours and the solvent was concentrated in vacuo. The residue was purified by silica gel (4.5 g) column chromatography eluting with chloroform/methanol (30:1) to give 1-[(R)-4-(6-(3-benzylureido)indol-1-yl)-1-(tert-butyldimethylsilyloxy)-2-butyl]imidazole-4-carboxamide (101 mg, 77%) as a pale yellow solid.

Provenance & Evidence