HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(2-Hydroxyphenyl)-4H-1,3-benzoxazin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Salicylamide | HCID 5147 | — |
| Reactant | Salicyloyl chloride | HCID 74041 | — |
| Product | 2-(2-Hydroxyphenyl)-4H-1,3-benzoxazin-4-one | HCID 135685723 | — |
Reaction Steps
106.0 g of salicyloyl chloride and 93.0 g of salicylamide are mixed and heated at 170° C. for 30 min until hydrogen chloride no longer escapes. The mixture is cooled and the residue is crystallized from ethanol. After drying, 2-(2-hydroxyphenyl)benz[e][1,3]oxazin-4-one is obtained as slightly yellow crystals of m.p. 206-208° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06596750B2 |
| Source dataset | uspto-grants-2003_07 |
| ORD ID | ord-b303e273ae9745e0aab89ba29443aaf0 |
| Source note | uspto-grants-2003_07 |