HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 3,5-Bis(2-hydroxyphenyl)-1-(4-nitrophenyl)-1H-[1,2,4]triazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Nitrophenylhydrazine hydrochloride | HCID 5463401 | — |
| Reactant | 2-(2-Hydroxyphenyl)-4H-1,3-benzoxazin-4-one | HCID 135685723 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3,5-Bis(2-hydroxyphenyl)-1-(4-nitrophenyl)-1H-[1,2,4]triazole | HCID 135817492 | — |
Reaction Steps
1.0 g of 2-(2-hydroxyphenyl)benz[e][1,3]oxazin-4-one, 0.5 ml of triethylamine and 0.7 g of 4-nitrophenylhydrazine hydrochloride are boiled under reflux for 1 h in 10 ml of ethanol. On cooling, the product precipitates in crystalline form. It is filtered off and washed with ethanol. After drying, 3,5-bis(2-hydroxyphenyl)-1-(4-nitrophenyl)-1H-[1,2,4]triazole remains as colorless crystals of m.p. 180-183° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06596750B2 |
| Source dataset | uspto-grants-2003_07 |
| ORD ID | ord-44f008fe48904470b828b0110ede743c |
| Source note | uspto-grants-2003_07 |