Ethyl [3,5bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]acetate → HCID 135817462, compound

HRID 1358528Notes

Reaction equation

HRID 1358528 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:12]=[C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[OH:19])[N:10]([CH2:20][C:21](OCC)=[O:22])[N:9]=1>C(CN)O>[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:12]=[C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[OH:19])[N:10]([CH2:20][C:21]([NH:10][CH2:20][CH2:21][OH:22])=[O:22])[N:9]=1

Participants

3

Reactant 1

HCID 135914986Ethyl [3,5bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]acetate

Product 1

HCID 135817462HCID 135817462, compound

Reagents, catalysts & solvents 1

HCID 700EthanolamineSolvent

Procedure

2.0 g of ethyl [3,5-bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]acetate (Example 2) are dissolved in 10 ml of ethanolamine and stirred at room temperature for 2 h. The mixture is concentrated to dryness in vacuo and the residue is crystallized from isopropanol. After drying, 2-[3,5-bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]-N-(2-hydroxyethyl)acetamide remains as colorless crystals of m.p. 208-211° C.

Workup

  1. concentrationThe mixture is concentrated to dryness in vacuo
  2. customthe residue is crystallized from isopropanol
  3. customAfter drying

Sources & evidence

ORD record
ord-277beb0a379643c4932c93b01c97c5d3
Source dataset
uspto-grants-2003_07
Patent number
US06596750B2

Reaction notes

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