反应详情

A mixture of 8.2 g (0.043 mol) of 2,3-dihydro-4-carboxybenzoxepine in 150 ml of ethanol and 5 ml of concentrated sulphuric acid is brought to reflux for 6 hours. The reaction mixture is subsequently concentrated under reduced pressure and the residue is taken up in water. The combined mixture is extracted with ethyl acetate. The organic phase is then washed with sodium bicarbonate and then with water and dried over anhydrous sodium sulphate before being concentrated under reduced pressure. 8.5 g of an orange oil are thus obtained.

1. temperatureto reflux for 6 hours
2. concentrationThe reaction mixture is subsequently concentrated under reduced pressure
3. extractionThe combined mixture is extracted with ethyl acetate
4. washThe organic phase is then washed with sodium bicarbonate
5. dry with materialwith water and dried over anhydrous sodium sulphate
6. concentrationbefore being concentrated under reduced pressure