1,4-Dioxane hydrochloride → HCID 69871986, compound

HRID 1358564Notes

Reaction equation

HRID 1358564 reaction equation
[CH3:1][N:2]1[C:6]2[CH:7]=[C:8]([O:11][CH3:12])[CH:9]=[CH:10][C:5]=2[N:4]=[C:3]1[CH2:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]([CH3:27])([OH:26])[C:22]([O:24]C)=[O:23])=[CH:17][CH:16]=1.[ClH:28].O1CCOCC1>CO>[ClH:28].[CH3:1][N:2]1[C:6]2[CH:7]=[C:8]([O:11][CH3:12])[CH:9]=[CH:10][C:5]=2[N:4]=[C:3]1[CH2:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]([CH3:27])([OH:26])[C:22]([OH:24])=[O:23])=[CH:17][CH:16]=1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 69871301HCID 69871301, compound

Product 1

HCID 69871986HCID 69871986, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of methyl 4-(1-methyl-6-methoxy-1H-benzimidazol-2-ylmethoxy)phenyllactate (0.2 g), methanol (5 ml) and 4N hydrogen chloride/dioxane (10 ml) was stirred at room temperature for 2 hours. The reaction mixture was concentrated to give crystals. The crystals were washed with a mixture of methanol and ether to afford the title compound (0.2 g, mp 193-195° C.).

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customto give crystals
  3. washThe crystals were washed with a mixture of methanol and ether

Sources & evidence

ORD record
ord-43984caff31640c2bc1b81002e7aede0
Source dataset
uspto-grants-2003_07
Patent number
US06596751B2

Reaction notes

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