Anisole → HCID 69870678, compound

Participants

Reaction Steps

A mixture of 4-(6-methoxy-1-methyl-1H-benzimidazol-2-ylmethoxy)phenylalanine methyl ester (1.1 g), 2-benzoylcyclohexanone (0.7 g), palladium on carbon (10%, 0.2 g) and anisole (15 ml) was heated at reflux for 21 hours. Insoluble material of the reaction mixture was removed by filtration and the anisole of the filtrate was evaporated under reduced pressure. The residue was chromatographed on a silica gel column using hexane:ethyl acetate=1:2 as the eluant to afford the title compound (0.95 g, Rf=0.51 (thin layer chromatography on silica gel using hexane:ethyl acetate=1:3 as the eluant)).

Provenance & Evidence