Hydrochloric Acid → HCID 178503098, compound

Participants

Reaction Steps

A mixture of methyl 3-[4-(1-methyl-6-methylthio-1H-benzimidazol-2-ylmethoxy)phenyl]-2-methylthiopropionate hydrochloride (5.75 g), concentrated hydrochloric acid (100 ml) and 1,4-dioxane (100 ml) was heated at reflux for 90 minutes. The reaction mixture was concentrated to dryness. To the residue was added tetrahydrofuran and the mixture was irradiated with ultrasonic waves. The insoluble material was isolated by filtration, washed with ethyl acetate, dissolved in N,N-dimethylformamide and reprecipitated with ether to afford the title compound (5.02 g, mp 193-196° C.).

Provenance & Evidence