4-Fluorobenzyl bromide → HCID 18184955, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl 4-(t-butoxycarbonylmethoxy)phenyllactate (3.0 g), 4-fluorobenzylbromide (2.4 ml), silver oxide (9.0 g) and toluene (60 ml) was stirred at 80° C. under a nitrogen atmosphere for 3 hours. The reaction mixture was filtered and the filtrate was concentrated under reduced pressure. The residue was chromatographed on a silica gel column using hexane:ethyl acetate=5:1 as the eluant to afford the title compound (2.9 g, Rf=0.39: thin layer chromatography on a silica gel plate using hexane:ethyl acetate=3:1 as the eluant).

Provenance & Evidence