HCID 18184955, compound → HCID 18184946, compound

HRID 1358575Notes

Reaction equation

HRID 1358575 reaction equation
C([O:5][C:6]([CH2:8][O:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][CH:17]([O:22][CH2:23][C:24]2[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=2)[C:18]([O:20][CH3:21])=[O:19])=[CH:12][CH:11]=1)=[O:7])(C)(C)C>Cl.O1CCOCC1>[C:6]([CH2:8][O:9][C:10]1[CH:11]=[CH:12][C:13]([CH2:16][CH:17]([O:22][CH2:23][C:24]2[CH:25]=[CH:26][C:27]([F:30])=[CH:28][CH:29]=2)[C:18]([O:20][CH3:21])=[O:19])=[CH:14][CH:15]=1)([OH:7])=[O:5]

Participants

3

Reactant 1

HCID 18184955HCID 18184955, compound

Product 1

HCID 18184946HCID 18184946, compound

Reagents, catalysts & solvents 1

HCID 204431481,4-Dioxane hydrochlorideSolvent

Procedure

A solution of methyl 3-[4-(t-butoxycarbonylmethoxy)phenyl]-2-(4-fluorobenzyloxy)propionate (2.8 g) in 4N hydrogen chloride/dioxane (50 ml) was stirred at room temperature for 3 hours. The reaction mixture was concentrated under reduced pressure to afford the title compound (2.42 g, Rf=0.10: thin layer chromatography on a silica gel plate using hexane:ethyl acetate=5:1 as the eluant).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-a190387d3ded4ff4ae300e44aef4af6c
Source dataset
uspto-grants-2003_07
Patent number
US06596751B2

Reaction notes

Loading…