反应详情

A mixture of 4-t-butoxycarbonylmethoxy-N-(2-benzoylphenyl)alanine methyl ester (1.4 g), 4N hydrogen chloride/dioxane (10 ml) and dioxane (10 ml) was stirred at room temperature for 3 hours and allowed to stand overnight. The reaction mixture was concentrated under reduced pressure. To the residue was added toluene and the mixture was concentrated under reduced pressure. The residue was chromatographed on a silica gel column (LiChroprepDIOL (Merck)) using hexane: ethyl acetate=2:1−1:1 as the eluant to afford the title compound (0.87 g, Rf=0.53: thin layer chromatography on a silica gel plate using hexane: ethyl acetate=3:2 as the eluant).

1. waitto stand overnight
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. additionTo the residue was added toluene
4. concentrationthe mixture was concentrated under reduced pressure
5. customThe residue was chromatographed on a silica gel column (LiChroprepDIOL (Merck))