1,4-Dioxane hydrochloride → HCID 88030992, compound

HRID 1358585Notes

Reaction equation

HRID 1358585 reaction equation
[OH:1][C:2]1[CH:3]=[CH:4][C:5]([NH:17][C:18]([CH2:20][O:21][C:22]2[CH:27]=[CH:26][C:25]([CH2:28][CH:29]3[S:33][C:32](=[O:34])[NH:31][C:30]3=[O:35])=[CH:24][CH:23]=2)=O)=[C:6]([N:8](C)[C:9](=O)OC(C)(C)C)[CH:7]=1.[ClH:36].O1CCOCC1>>[ClH:36].[OH:1][C:2]1[CH:3]=[CH:4][C:5]2[N:17]=[C:18]([CH2:20][O:21][C:22]3[CH:23]=[CH:24][C:25]([CH2:28][CH:29]4[S:33][C:32](=[O:34])[NH:31][C:30]4=[O:35])=[CH:26][CH:27]=3)[N:8]([CH3:9])[C:6]=2[CH:7]=1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 86587630HCID 86587630, compound

Product 1

HCID 88030992HCID 88030992, compound

Procedure

A suspension of this carbamate (0.75 g) in 4N hydrogen chloride/dioxane (10 ml) was allowed to stand at room temperature for 19 hours. The solvent of the reaction mixture was evaporated under reduced pressure. Ethyl acetate was added to the residue and the mixture was treated with ultrasonic waves, filtered and then dried to afford the title compound (0.52 g, mp 217-220° C.).

Workup

  1. customThe solvent of the reaction mixture was evaporated under reduced pressure
  2. additionEthyl acetate was added to the residue
  3. additionthe mixture was treated with ultrasonic waves
  4. filtrationfiltered
  5. customdried

Sources & evidence

ORD record
ord-bb1e2e8f131a47708de68f8ed8faa14c
Source dataset
uspto-grants-2003_07
Patent number
US06596751B2

Reaction notes

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