HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hexamethylenetetramine → 4-Hydroxy-3,5-bis(isopropyl)benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hexamethylenetetramine | HCID 4101 | — |
| Reactant | Propofol | HCID 4943 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Hexane | HCID 8058 | — |
| Product | 4-Hydroxy-3,5-bis(isopropyl)benzaldehyde | HCID 82712 | 26% |
Reaction Steps
18 g of 2,6-di isopropyl phenol and 1.8 g HMTA (hexamethylene tetraamine) in 60 ml TFA (trifluoro acetic acid) was refluxed 3.5 hours. Workup, chromatography on silica gel (CH2Cl2) and trituration with hexane gave 5.3 g, 26% yield, white solid, mp-103° C. (3,5,-di-iso-propyl 4 hydroxybenzaldehyde). NMR CDCl3 δ 9.87 (1H, S, CHO), 7.63 (2H, S), 3.19 (2H, septet, J=7.7 Hz), 1.30 (12H, d, J=7.7 Hz).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06596878B2 |
| Source dataset | uspto-grants-2003_07 |
| ORD ID | ord-b1bc972960c047fb91438dffdba28186 |
| Source note | uspto-grants-2003_07 |