HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-Dimethylaniline → 4-Chloro-8-methylquinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-Dimethylaniline | HCID 949 | — |
| Reactant | Hexane | HCID 8058 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 8-Methylquinazolin-4(1H)-one | HCID 135471300 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 4-Chloro-8-methylquinazoline | HCID 18185618 | — |
Reaction Steps
4 g of 8-methyl 4-quinazolinone, 5 ml POCl3 and 5 ml dimethyl aniline in 40 ml toluene were refluxed 3.5 hours. Workup and trituration with hexane gave 2.6 g of 8-methyl 4 chloro quinazoline, mp-122° C. NMR CDCl3 δ 9.07 (1H, S), 8.12 (1H, d, J=7.7 Hz), 7.8 (1H, d, J=6.0 Hz), 7.60 (1H, t), 2.78 (3H, S).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06596878B2 |
| Source dataset | uspto-grants-2003_07 |
| ORD ID | ord-f3187c97ffbc40c494accd90541594cd |
| Source note | uspto-grants-2003_07 |