Water → HCID 9808463, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl 3,5-dihydroxybenzoate (100 mg, 0.595 mmol), 4-(trifluoromethylsulfonyl)chlorobenzene (291 mg, 2 equiv.) and potassium carbonate (330 mg, 4 equiv.) in DMF was heated to 100° C. overnight. The reaction was poured into water, extracted with EtOAc, washed the organic layer with water, brine, dried and concentrate. The residue was column chromatographed (1:2 EtOAc: Hex) to give 3,5-bis-(4-trifluoromethanesulfonyl-phenoxy)-benzoic acid methyl ester. 1HNMR (360 MHz, DMSO-d6) δ 8.12 (d, J=7.86 Hz, 4H), 7.67 (d, J=2.17 Hz, 2H), 7.61 (t, J=2.17 Hz, 1H), 7.42 (d, J=7.86 Hz, 4H), 3.85 (s, 3H, OCH3).

Provenance & Evidence