Sodium hydride → HCID 9868320, compound

Participants

Reaction Steps

Using procedure as in Example 10, a reaction of methyl 4-(2-hydroxyethoxy)benzoic acid methyl ester (100 mg, 0.51 mmol), NaH (22 mg, 1.1 equiv.) and 2-nitro-4-(trifluoromethylsulfonyl)chlorobenzene (148 mg, 1 equiv.) afforded 4-[2-(2-nitro-4-trifluoromethanesulfonyl-phenoxy)-ethoxy]-benzoic acid methyl ester. 1HNMR (300 MHz, DMSO-d6) δ 8.64 (d, J=2.5 Hz, 1H), 8.39 (dd, J=2.5 & 8.9 Hz, 1H), 7.89 (d, J=8.8 Hz, 2H), 7.83 (d, J=8.9 Hz, 1H), 7.06 (d, J=8.8 Hz, 2H), 4.76 (m, 2H), 4.46 (m, 2H), 3.80 (s, 3H, OCH3). MS-EI m/z 449 [M+].

Provenance & Evidence