Sodium hydride → HCID 9938746, compound

Participants

Reaction Steps

Using procedure as in example 10, a reaction of methyl 1-[3,5-di(trifluoromethyl)phenyl]-5-hydroxy-1H-pyrazole-3-carboxylate (100 mg, 0.282 mmol), NaH (12 mg, 1.1 equiv.) and 2-nitro-4-(trifluoromethylsulfonyl)chlorobenzene (82 mg, 1 equiv.) afforded 1-(3,5-bis-trifluoromethyl-phenyl)-5-(2-nitro-4-trifluoromethanesulfonyl-phenoxy)-1H-pyrazole-3-carboxylic acidmethyl ester. 1HNMR (300 MHz, DMSO-d6) δ 8.76 (d, J=2.1 Hz, 1H), 8.58 (dd, J=2.1 & 8.2 Hz, 1H), 8.42 (s, 2H), 8.30 (s, 1H), 8.13 (d, J=8.2 Hz, 1H), 6.76 (m, 1H), 3.7 (s, 3H, OCH3). MS-EI m/z 607 [M+].

Provenance & Evidence