m-Phenylenediacetic acid → HCID 9851819, compound

HRID 1358759Notes

Reaction equation

HRID 1358759 reaction equation
[F:1][C:2]([S:5]([C:8]1[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][CH:9]=1)(=[O:7])=[O:6])([F:4])[F:3].[C:15]1([CH2:25][C:26]([OH:28])=O)[CH:20]=[CH:19][CH:18]=[C:17]([CH2:21][C:22]([OH:24])=O)[CH:16]=1>>[F:1][C:2]([F:4])([F:3])[S:5]([C:8]1[CH:13]=[CH:12][C:11]([NH:14][C:22](=[O:24])[CH2:21][C:17]2[CH:18]=[CH:19][CH:20]=[C:15]([CH2:25][C:26](=[O:28])[NH:14][C:11]3[CH:12]=[CH:13][C:8]([S:5]([C:2]([F:4])([F:1])[F:3])(=[O:7])=[O:6])=[CH:9][CH:10]=3)[CH:16]=2)=[CH:10][CH:9]=1)(=[O:6])=[O:7]

Participants

3

Reactant 2

HCID 29788m-Phenylenediacetic acidHCID 1363154-Aminophenyl trifluoromethyl sulphone

Product 1

HCID 9851819HCID 9851819, compound

Procedure

Same procedure as example 20 except 4-aminophenyl trifluoromethyl sulfone and 1,3-phenylenediacetic acid were used. 1H NMR (300 MHz, DMSO-d6) δ 10.91 (s, 2H, 2×NH), 8.05 (d, J=9.1 Hz, 4H), 7.99 (d, J=9.1 Hz, 4H), 7.21-7.29 (m, 4H), 3.73 (s, 4H, 2×CH2). MS 609 [M++1].

Sources & evidence

ORD record
ord-b1c49e7beab04fad84dbcf19e827fbec
Source dataset
uspto-grants-2003_07
Patent number
US06596772B1

Reaction notes

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