Potassium Carbonate → HCID 18185320, compound

Participants

Reaction Steps

A mixture of 3-(4-nitroanilino)-1,2-propanediol (71 mg, 0.33 mmol), 1-chloro-2-nitro-4-trifluoromethanesulfonyl-benzene (135 mg, 0.47 mmol) and potasium carbonate (190 mg, 1.33 mmol) in acetonitrile (2 mL) was heated to reflux for 2 days. The reaction was diluted with chloroform/isopropanol mixture, washed with brine, dried, concentrated and column chromatographed to give the title compound (di-arylated) and 1-(4-nitro-phenylamino)-3-(2-nitro-4-trifluoromethanesulfonyl-phenoxy)-propan-2-ol (mono-arylated). 1H NMR (360 MHz, DMSO-d6) δ 8.63 (d, 1H), 8.37 (dd, 1H), 8.30 (d, J=8.8 Hz, 2H), 7.83 (d, 1H), 7.66 (d, J=8.8 Hz, 2H), 7.50 (dd, 1H), 7.42 (d, 1H), 7.31 (d, 1H), 4.91 (m, 1H), 4.76 (m, 2H), 4.15 (dd, 1H), 3.91 (dd, 1H).

Provenance & Evidence