1,2-Dichloroethane → HCID 69631947, compound

Participants

Reaction Steps

To 1-Methyl-5-Trifluoromethansulfonylamino-1H-Indole-2-Carboxylic Acid (0.21 g, 0.65 mmol) in 8 ml of DMF was added HOBt (96 mg, 0.71 mmol), EDC (145 mg, 0.78 mmol), TEA (131 mg, 1.3 mmol), and aniline (0.65 ml, 72 mmol). The reaction mixture was stirred at room temperature for a day. The reaction was diluted with 200 ml of methylene dichloride and washed with water and brine, then concentrated. The residue was purified by flash column with 50% EtOAc/Hexane to give 0.13 g of 1-Methyl-5-trifluoromethansulfonylamino-1H-indole-2-carboxylic acid phenylamide as a beige solid. 1H-NMR (400 MHz, DMSO-d6) δ 11.61 (s, 1H, SNH), 10.37 (s, 1H, NHCO), 7.78 (d, J=8 Hz, 2H, ArH-o), 7.63 (d, J=9 Hz, 1H, H-7), 7,61 (d, J=2 Hz, 1H, H-4), 7.37 (t, J=8 Hz, 2H, ArH-m), 7.32 (s, 1H, H-3), 7.20 (dd, J=2, 9 Hz, 1H, H-6), 7.12 (t. J=7.4 Hz, 1H. ArH-p).MS m/z 396 (M−H).

Provenance & Evidence