Methyl 4-aminobenzoate → HCID 18185369, compound

HRID 1358774Notes

Reaction equation

HRID 1358774 reaction equation
[CH3:1][C:2]1[N:3]([CH2:19][C:20]([OH:22])=O)[C:4]2[C:9]([CH:10]=1)=[CH:8][C:7]([NH:11][S:12]([C:15]([F:18])([F:17])[F:16])(=[O:14])=[O:13])=[CH:6][CH:5]=2.C[O:24][C:25](=[O:33])[C:26]1[CH:31]=[CH:30][C:29]([NH2:32])=[CH:28][CH:27]=1>>[CH3:1][C:2]1[N:3]([CH2:19][C:20]([NH:32][C:29]2[CH:30]=[CH:31][C:26]([C:25]([OH:33])=[O:24])=[CH:27][CH:28]=2)=[O:22])[C:4]2[C:9]([CH:10]=1)=[CH:8][C:7]([NH:11][S:12]([C:15]([F:17])([F:16])[F:18])(=[O:13])=[O:14])=[CH:6][CH:5]=2

Participants

3

Reactant 2

HCID 12082Methyl 4-aminobenzoateHCID 18185310HCID 18185310, compound

Product 1

HCID 18185369HCID 18185369, compound

Procedure

Same procedure as Example 82 except (2-Methyl-5-trifluoromethanesulfonylamino-indol-1-yl)-acetic acid and 4-aminobenzoic methyl ester was used. 1H-NMR (400 MHz, DMSO-d6) δ 12.72 (s, 1H, COOH), 11.45 (s, 1H, SNH), 10,73 (s, 1H, NHCO), 7.90 (d, J=7 Hz, 2H, ArH), 7.70 (d, 2H, ArH), 7.38 (d, J=9 Hz, 1H, H-7), 7.32 (d, J=2 Hz, 1H, H-4), 6.94 (dd, J=2, 8 Hz, 1H, H-6), 6.28 (s, 1H, H-3), 5.04 (s, 2H, CH2), 2.38 (s, 3H, CH3), MS m/z 454 (M−H).

Sources & evidence

ORD record
ord-ba63cba3d5e04551af0d19a4333053c2
Source dataset
uspto-grants-2003_07
Patent number
US06596772B1

Reaction notes

Loading…