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Potassium Carbonate → 2-[4-(4-Benzylaminosulfonylmethylbenzyl)-phenyl]amino-imidazoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Chloro-4,5-dihydroimidazole | HCID 236236 | — |
| 反応物 | 4-(4-Benzylaminosulfonylmethylbenzyl)-phenylamine | HCID 21876959 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | 2-[4-(4-Benzylaminosulfonylmethylbenzyl)-phenyl]amino-imidazoline | HCID 12094388 | — |
反応手順
A mixture of 4-(4-benzylaminosulfonylmethylbenzyl)-phenylamine (39 mg) and 2-chloro-imidazoline base (1 eq) in 2-propanol was heated under reflux for 16 hours. A dilute solution of potassium carbonate was poured into the mixture and extracted with dichloromethane (4×15 mL). Solvents were evaported to give 2-[4-(4-benzylaminosulfonylmethylbenzyl)-phenyl]amino-imidazoline as a solid (41.7 mg), m.p. 115-118° C.; Analysis for C24H25ClN4O2S•H2O: Calc.: C, 58.94; H, 5.98; N, 11.46; Found: C, 59.01; H, 5.91; N, 11.30.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06596876B2 |
| 出典データセット | uspto-grants-2003_07 |
| ORD ID | ord-c577988172f74663b1c8645b855b902f |
| 出典メモ | uspto-grants-2003_07 |