HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4-Pyrrolidin-1-ylcarbonylbenzyl)-nitrobenzene → 4-[4-(1-Pyrrolidinecarbonyl)benzyl]-phenylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4-Pyrrolidin-1-ylcarbonylbenzyl)-nitrobenzene | HCID 12094391 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-[4-(1-Pyrrolidinecarbonyl)benzyl]-phenylamine | HCID 12094390 | 102.5% |
Reaction Steps
A mixture of 4-(4-pyrrolidin-1-ylcarbonylbenzyl)-nitrobenzene (202 mg, 065 mmol), 10% palladium on carbon (110 mg), and ethanol (20 mL) was hydrogenated at 40 psi for 16 hours. The mixture was filtered through a Celite pad, and solvents evaporated to give 4-[4-(1-pyrrolidinecarbonyl)benzyl]-phenylamine as a white solid (187 mg, 99%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06596876B2 |
| Source dataset | uspto-grants-2003_07 |
| ORD ID | ord-b155468c1fb640769bcb81dde2cf83db |
| Source note | uspto-grants-2003_07 |