反应详情

A solution containing 0.17 cm3 of 2-pyridine methanethiol, 81 mg of sodium methylate, 234 mg of the product obtained in Stage D of Example 3 and 4 cm3 of methanol is heated for 3 hours under reflux. The methanol is distilled off, the residue is taken up with ethyl acetate, washed with water, dried and brought to dryness under reduced pressure. 360 mg of residue is collected which is chromatographed on silica (eluant ethyl acetate-essence G 8/2) and in this way 280 mg of expected product is obtained.

1. temperatureis heated for 3 hours
2. temperatureunder reflux
3. distillationThe methanol is distilled off
4. washwashed with water
5. customdried
6. custom360 mg of residue is collected which
7. customis chromatographed on silica (eluant ethyl acetate-essence G 8/2) and in this way 280 mg of expected product
8. customis obtained