Acetic Anhydride → HCID 21138139, compound

HRID 1358876Notes

Reaction equation

HRID 1358876 reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([C@H:13]2[CH2:30][C@@:28]3([CH3:29])[C@@H:24]([CH2:25][CH2:26][C:27]3=[O:31])[C@H:23]3[C:14]2=[C:15]2[C:20]([CH2:21][CH2:22]3)=[CH:19][C:18](=[O:32])[CH2:17][CH2:16]2)=[CH:9][CH:8]=1.C(OC(=O)C)(=O)C.C(Br)(=O)C>>[OH:32][C:18]1[CH:17]=[CH:16][C:15]2[C@@H:14]3[C@H:23]([C@H:24]4[C@@:28]([CH2:30][C@@H:13]3[C:10]3[CH:9]=[CH:8][C:7]([O:6][CH2:5][CH2:4][CH2:3][CH2:2][Cl:1])=[CH:12][CH:11]=3)([CH3:29])[C:27](=[O:31])[CH2:26][CH2:25]4)[CH2:22][CH2:21][C:20]=2[CH:19]=1

Participants

4

Reactant 3

HCID 7918Acetic AnhydrideHCID 10482Acetyl bromideHCID 86585313HCID 86585313, compound

Product 1

HCID 21138139HCID 21138139, compoundYield 109,629.602%

Procedure

The operation is carried out as in Stages B and C of Example 3 starting with 1.35 mg of the product obtained in Stage A above using 1.4 cm3 of acetic anhydride and 0.7 cm3 of acetyl bromide. 1.48 g of desired product is obtained.

Sources & evidence

ORD record
ord-436f177680ae40fabac218232a168f6d
Source dataset
uspto-grants-2003_07
Patent number
US06596885B2

Reaction notes

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